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Systemic Lupus Erythematosus (SLE)


What is systemic lupus erythematosus?

Systemic Lupus Erythematosus is an autoimmune disease that occurs when the immune system attacks its own tissues, resulting in widespread inflammation and tissue damage in the affected organs. Systemic lupus erythematosus may affect the joints, brain, skin, lungs, kidneys and blood vessels. The disease ranges from mild to life-threatening. Systemic lupus erythematosus is a chronic condition where the symptoms tend to cycle in alternate periods of flares or flare-ups and remissions.


What are the symptoms of systemic lupus erythematosus?
Systemic lupus erythematosus symptoms vary and can change over time. Symptoms may include:

  • Joint pain
  • Oral ulcers
  • Joint swelling
  • Severe fatigue
  • Hair loss
  • Anaemia
  • Headaches
  • Blood clotting problems
  • A rash on the cheeks and nose called a butterfly rash
  • Fingers that are turning white or blue

Other symptoms such as sun sensitivity, lung problems, heart problems, kidney problems, seizures and blood cell and immunological abnormalities may be experienced depending on the part of the body that the disease is attacking. Lupus symptoms are also symptoms of several other diseases, which then makes the diagnosis very tricky. If you are experiencing any of the mentioned symptoms, seek medical attention. Your doctor will then gather the information needed to make an accurate diagnosis.


What are the treatment options for systemic lupus erythematosus?

There is no cure for systemic lupus erythematosus, but the main goal of treatment is to ease symptoms. Systemic lupus erythematosus treatment varies depending on how severe the symptoms are and which part of the body is affected. The treatment may include:

  • Steroid creams for the rashes.
  • Antimalarial drugs for skin and joint problems.
  • Anti-inflammatory medications for joint pain and stiffness.
  • Corticosteroids to help minimise the immune response.
  • Disease-modifying drugs or targeted immune system agents for more severe cases.


FAQ:

1How is systemic lupus erythematosus diagnosed?
To diagnose systemic lupus erythematosus, Dr Ambaram will examine your child and may also conduct tests such as blood tests, a urinalysis and possibly a chest x-ray.
2What are the long-term complications of systemic lupus erythematosus?
Over time, systemic lupus erythematosus may damage or cause complications throughout the body. Possible complications may include:
  • A stroke
  • Inflammation of the heart or pericarditis
  • Blood clots and inflammation of the blood vessels or vasculitis
  • Seizures
  • Inflammation of the lung tissue and the lining of the lung, or pleuritis
  • Kidney inflammation
  • Decreased kidney function
  • Kidney failure
3Who is at risk of systemic lupus erythematosus?
Systemic lupus erythematosus affects people of all ages, including children. It is rare before five years of age and is more prevalent after the first decade of life.
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What is a paediatric rheumatologist?


A paediatric rheumatologist is a doctor that cares for children and adolescents with medical conditions such as inflammatory and non-inflammatory musculoskeletal disease and autoimmune diseases. Autoimmune inflammatory diseases include juvenile dermatomyositis, juvenile Idiopathic arthritis, vasculitis, scleroderma, systemic lupus erythematous and periodic fever syndromes. Non-inflammatory diseases include chronic musculoskeletal pain syndromes, juvenile hypermobility and growing pains.